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M9630436.TXT
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1996-02-27
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Document 0436
DOCN M9630436
TI Evidence for anti-Plasmodium falciparum antibodies that cross-react with
human T-lymphotropic virus type I proteins in a population in Irian
Jaya, Indonesia.
DT 9603
AU Porter KR; Liang L; Long GW; Bangs MJ; Anthony R; Andersen EM; Hayes CG;
Infectious Diseases Threat Assessment Program, Naval Medical; Research
Institute, Bethesda, Maryland 20852, USA.
SO Clin Diagn Lab Immunol. 1994 Jan;1(1):11-5. Unique Identifier : AIDSLINE
MED/96050771
AB This study was performed to demonstrate the presence of anti-Plasmodium
falciparum antibodies in a population living in Irian Jaya, Indonesia
that cross-react with human T-lymphotropic virus type I (HTLV-I)
proteins. Serum samples from 63 volunteers living in Oksibil, a secluded
highland valley in Irian Jaya, were tested for anti-P. falciparum
antibodies by an immunofluorescence assay and for anti-HTLV-I antibodies
by an enzyme immunoassay (EIA). All samples were positive for anti-P.
falciparum antibodies at titers of > or = 1:256. Twenty-four samples
were reactive by EIA for HTLV-I, and of these, 23 were tested by western
blotting (immunoblotting). Five of the 23 samples were classified as
western blot positive and 18 were classified as western blot
indeterminate. In competitive blocking assays with malaria proteins,
western blot immunoreactivity to all HTLV-I Gag proteins was either
reduced or eliminated. Significant reductions in the HTLV-I EIA optical
density values of the Oksibil sera occurred when the sera were
competitively blocked with the malaria antigens. The optical density
values of HTLV-I-positive control sera showed no significant change.
Competitive blocking with HTLV-I antigens produced reductions in the
optical density values of both the Oksibil sera and the HTLV-I-positive
control sera. These data suggest that in this population, anti-P.
falciparum antibodies are cross-reactive with HTLV-I proteins in the
western blot and EIA tests.
DE Animal Antibodies, Protozoan/*CHEMISTRY Binding, Competitive Cross
Reactions Human HTLV-I Antibodies/CHEMISTRY HTLV-I
Antigens/*IMMUNOLOGY Indonesia/EPIDEMIOLOGY Malaria,
Falciparum/EPIDEMIOLOGY/IMMUNOLOGY/VIROLOGY Plasmodium
falciparum/*IMMUNOLOGY Support, U.S. Gov't, Non-P.H.S. Viral
Proteins/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).